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Supplements - to Take or Not to Take?


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question...whats better for fat loss xenadrine or ripped fuel? hydroxycut doesnt work for me and im using xenadrine. but i want to try something new and i was wondering if ripped fuel is better... thanks!

 

Hydroxycut owes their fame to ephedra and without it I feel the product was almost worthless. The US lifted the ban in April 05 and some manufacturers are putting it back into their product. This is one of the best known ingredient used to reduce your appetite and give you energy during the day. Find a product that contains ephedra and you’ll see better results then just caffeine alone.

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mga bro meron ako nakit kanian lipo6 fat burner yun daw ang ok ngayon has anybody tried it na? pati nutrifit or nutrafit nakakapayat dat talaga (of course with diet and exercise) nadinig niyo na bato?

 

medyo na-trauma ako sa mga slimming supplements na yan kasi yung slimming tea na ininom ko once made me go to the restroom every minute istorbo sa trabaho, parang nagka-lbm ako. sana may mga slimming / fat burning supplements na hindi nakakapagpatae. :unsure:

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Guys....let's face it....some people are out there about to take or may have already taken another dose of steroids and there is nothing we can do to make them change their minds. My question is, what are the supplements needed to complement with the steroid use so as to compensate/protect (I just don't have a word for it) for any damage the body may have to endure?

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Hi,

Me tanong lang ako.. pwde bang e-stack ang creatine pati tribulus ? Effective ba ang swole v.2 ng syntrax ?

bro,

my answer, through research, is NO...the reason why is because tribulus is a diuretic (tending to increase urine flow)...which means it will negate the effect of creatine since it does the opposite by increasing muscle cell mass by way of increased water retention...it will be like taking xenadrine/hydroxycut (with caffeine) AND creatine at the same time...studies strongly recommend NOT to take caffeine while taking creatine....just my two cents...

 

may i ask what is your primary goal?...to lose or gain weight?....thanks...noah

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question...whats better for fat loss xenadrine or ripped fuel? hydroxycut doesnt work for me and im using xenadrine. but i want to try something new and i was wondering if ripped fuel is better... thanks!

just my two cents...some supplements are good for some people but not for the others...it all depends on how your body reacts to the supplements or the other way around...what i suggest is to try one and then switch to the other and compare the results of the two...God Bless and stay healthy...noah

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hint-of-lime,

 

Thank you for your research into this matter.  The abuse of steroids can lead to a lot of unwanted side-effects.  But what does your research say on healthy adult males cycling steroids?  The US has banned steroids and even made them illegal to posses without a doctor’s prescription.  What they don't tell you is the American Medical Association, Dept of Health and Human services and Drug Enforcement Agency (DEA) all oppose such a move. 

 

I have not found a long term study that can point distinctly to the negative side-effects of anabolic steroids when taken in a responsible manner, ie. cycling the drug in healthy adult males.  If you can find such a study I would really like to see it.

 

Peace

 

Gryphon, I am sure that whatever reasons the AMA, DEA, and DOHHS have for opposing such a move by the US to ban steroids and make their possession illegal is not in any way related to the use by athletes of these drugs. Needless to say, all properly trained doctors in sports medicine are against its use. You are right, there are no long term studies I am aware of that deal with the negative side-effects of anabolic steroids when taken in a "responsible manner" because, at this point in time, and with the currently available types of steroids, there is no such thing as a "responsible manner" of taking it. Unfortunately, studies on "cycling of steroids in healthy adult males" can never materialize because of all the ethical and legal barriers already in place. What I have found, however, in my review of literature on www.pubmed.com are studies which quote "long term" effects of steroids. Here you can see behavioural studies, animal studies, case studies, cohort studies on what the authors claim are long term effects of steroid use.

 

Peace to you, too! :) *med

 

CNS Drugs. 2005;19(7):571-95.

Behavioural manifestations of anabolic steroid use.

Trenton AJ, Currier GW.

Department of Psychiatry, University of Rochester School of Medicine, Rochester, New York 14642, USA.

 

The use of anabolic androgenic steroids (AAS) for gains in strength and muscle mass is relatively common among certain subpopulations, including athletes, bodybuilders, adolescents and young adults.Adverse physical effects associated with steroid abuse are well documented, but more recently, increased attention has been given to the adverse psychiatric effects of these compounds. Steroids may be used in oral, 17alpha-alkylated, or intramuscular, 17beta-esterified, preparations. Commonly, steroid users employ these agents at levels 10- to 100-fold in excess of therapeutic doses and use multiple steroids simultaneously, a practice known as 'stacking'. Significant psychiatric symptoms including aggression and violence, mania, and less frequently psychosis and suicide have been associated with steroid abuse. Long-term steroid abusers may develop symptoms of dependence and withdrawal on discontinuation of AAS. Treatment of AAS abusers should address both acute physical and behavioural symptoms as well as long-term abstinence and recovery. To date, limited information is available regarding specific pharmacological treatments for individuals recovering from steroid abuse. This paper reviews the published literature concerning the recognition and treatment of behavioural manifestations of AAS abuse.

 

 

Horm Behav. 2004 Aug;46(2):193-203.

Long-term effects of pubertal anabolic-androgenic steroid exposure on reproductive and aggressive behaviors in male rats.Farrell SF, McGinnis MY.

Center for Anatomy and Functional Morphology, Mount Sinai School of Medicine, New York, NY 10029, USA.

 

The current study examined acute and long-term effects of anabolic-androgenic steroid (AAS) exposure during puberty on copulation, vocalizations, scent marking, and intermale aggression, both with and without tail pinch, in intact male rats. Animals received 5 mg/kg of testosterone, nandrolone, stanozolol, or vehicle, beginning at puberty. After 5 weeks, behavior tests were performed while continuing AAS injections. AAS treatment was then discontinued. Behaviors were tested during 3-5 weeks, 9-11 weeks, and 15-17 weeks of withdrawal. During AAS administration, stanozolol males showed significant reductions in all behaviors compared with controls, except aggression with tail pinch. Nandrolone treatment significantly reduced vocalizations and scent marking, and testosterone had no significant effect on behavior. During withdrawal, behaviors in stanozolol males recovered to control levels at variable rates: aggression at 4 weeks; mounts, vocalizations, and scent marking at 9 weeks; and ejaculations at 15 weeks of withdrawal. Stanozolol males showed significantly higher levels of tail pinch-induced aggression during every withdrawal test. Nandrolone-treated males scent-marked at control levels by 9 weeks withdrawal but displayed significantly fewer vocalizations and significantly more tail pinch-induced aggression than controls for the entire study. Testosterone-treated males scent-marked significantly below controls at 3 weeks withdrawal and showed significantly more tail pinch-induced aggression at 5 weeks withdrawal. All three AAS significantly increased tail pinch-induced aggression compared with corresponding nontail pinch tests, even at study endpoint. These results suggest that alterations in androgen-dependent behaviors by pubertal AAS exposure can persist long after drug exposure, and some effects may even be permanent.

 

Sports Med. 2004;34(8):513-54.

Effects of androgenic-anabolic steroids in athletes.

Hartgens F, Kuipers H.

Department of Surgery, Outpatient Clinic Sports Medicine, University Hospital Maastricht, and Sports Medicine Center Maastricht, Maastricht, The Netherlands. fhartgens@home.nl

 

Androgenic-anabolic steroids (AAS) are synthetic derivatives of the male hormone testosterone. They can exert strong effects on the human body that may be beneficial for athletic performance. A review of the literature revealed that most laboratory studies did not investigate the actual doses of AAS currently abused in the field. Therefore, those studies may not reflect the actual (adverse) effects of steroids. The available scientific literature describes that short-term administration of these drugs by athletes can increase strength and bodyweight. Strength gains of about 5-20% of the initial strength and increments of 2-5 kg bodyweight, that may be attributed to an increase of the lean body mass, have been observed. A reduction of fat mass does not seem to occur. Although AAS administration may affect erythropoiesis and blood haemoglobin concentrations, no effect on endurance performance was observed. Little data about the effects of AAS on metabolic responses during exercise training and recovery are available and, therefore, do not allow firm conclusions. The main untoward effects of short- and long-term AAS abuse that male athletes most often self-report are an increase in sexual drive, the occurrence of acne vulgaris, increased body hair and increment of aggressive behaviour. AAS administration will disturb the regular endogenous production of testosterone and gonadotrophins that may persist for months after drug withdrawal. Cardiovascular risk factors may undergo deleterious alterations, including elevation of blood pressure and depression of serum high-density lipoprotein (HDL)-, HDL2- and HDL3-cholesterol levels. In echocardiographic studies in male athletes, AAS did not seem to affect cardiac structure and function, although in animal studies these drugs have been observed to exert hazardous effects on heart structure and function. In studies of athletes, AAS were not found to damage the liver. Psyche and behaviour seem to be strongly affected by AAS. Generally, AAS seem to induce increments of aggression and hostility. Mood disturbances (e.g. depression, [hypo-]mania, psychotic features) are likely to be dose and drug dependent. AAS dependence or withdrawal effects (such as depression) seem to occur only in a small number of AAS users. Dissatisfaction with the body and low self-esteem may lead to the so-called 'reverse anorexia syndrome' that predisposes to the start of AAS use. Many other adverse effects have been associated with AAS misuse, including disturbance of endocrine and immune function, alterations of sebaceous system and skin, changes of haemostatic system and urogenital tract. One has to keep in mind that the scientific data may underestimate the actual untoward effects because of the relatively low doses administered in those studies, since they do not approximate doses used by illicit steroid users. The mechanism of action of AAS may differ between compounds because of variations in the steroid molecule and affinity to androgen receptors. Several pathways of action have been recognised. The enzyme 5-alpha-reductase seems to play an important role by converting AAS into dihydrotestosterone (androstanolone) that acts in the cell nucleus of target organs, such as male accessory glands, skin and prostate. Other mechanisms comprises mediation by the enzyme aromatase that converts AAS in female sex hormones (estradiol and estrone), antagonistic action to estrogens and a competitive antagonism to the glucocorticoid receptors. Furthermore, AAS stimulate erythropoietin synthesis and red cell production as well as bone formation but counteract bone breakdown. The effects on the cardiovascular system are proposed to be mediated by the occurrence of AAS-induced atherosclerosis (due to unfavourable influence on serum lipids and lipoproteins), thrombosis, vasospasm or direct injury to vessel walls, or may be ascribed to a combination of the different mechanisms. AAS-induced increment of muscle tissue can be attributed to hypertrophy and the formation of new muscle fibres, in which key roles are played by satellite cell number and ultrastructure, androgen receptors and myonuclei. Copyright 2004 Adis Data Information BV

 

 

Ital Heart J. 2003 Dec;4(12):829-37.

Arrhythmogenic effects of illicit drugs in athletes.

Furlanello F, Bentivegna S, Cappato R, De Ambroggi L.

Center of Clinical Arrhythmia and Electrophysiology, Istituto Policlinico San Donato, University of Milan, San Donato, Milanese, MI, Italy. furlanello@interfree.it

 

Cardiac arrhythmias are among the most important causes of non-eligibility to sports activities, and may be due to different causes (cardiomyopathies, myocarditis, coronary abnormalities, valvular diseases, primary electrical disorders, abuse of illicit drugs). The list of illicit drugs banned by the International Olympic Committee and yearly updated by the World Anti-Doping Agency includes the following classes: stimulants, narcotics, anabolic agents (androgenic steroids and others such as beta-2 stimulants), peptide hormones, mimetics and analogues, diuretics, agents with an antiestrogenic activity, masking agents. Almost all illicit drugs may cause, through a direct or indirect arrhythmogenic effect, in the short, medium or long term, a wide range of cardiac arrhythmias (focal or reentry type, supraventricular and/or ventricular), lethal or not, even in healthy subjects with no previous history of cardiac diseases. Therefore, given the widespread abuse of illicit drugs among athletes, in the management of arrhythmic athletes the cardiologist should always take into consideration the possibility that the arrhythmias be due to the assumption of illicit drugs (sometimes more than one type), especially if no signs of cardiac diseases are present. On the other hand, in the presence of latent underlying arrhythmogenic heart disease including some inherited cardiomyopathies at risk of sudden cardiac death, illicit drugs could induce severe cardiac arrhythmic effects.

 

 

Orv Hetil. 2003 Dec 7;144(49):2425-7.

[Severe nephrotic syndrome in a young man taking anabolic steroid and creatine long term]

Revai T, Sapi Z, Benedek S, Kovacs A, Kaszas I, Viranyi M, Winkler G.

Szent Janos Korhaz, II. Belgyogyaszat, Nefrologia.

 

Anabolic steroids and creatine supplementation is one of the current abuse used by body builders. It is less known that this combination beside of many deleterious effects may also cause renal damage. Authors report a case of diffuse membranoproliferative glomerulonephritis type I in a 22-year-old man who had been taking continuously methandion in a large quantity and 200 grams of creatine daily, and was sent to the outpatient nephrologic unit with typical clinical signs of nephrosis syndrome. They also call attention to the role of the continuously consumed creatine in the renal failure.

 

 

Sports Med. 2002;32(2):83-94.

Steroid use and long-term health risks in former athletes.

Parssinen M, Seppala T.

Laboratory of Substance Abuse, National Public Health Institute, Helsinki, Finland. miia.parssinen@ktl.fi

 

This article focuses on anabolic steroid adverse effects on the cardiovascular system and mental health issues as well as the possible increase in the incidence of neoplasms in anabolic steroid users. On the basis of findings in the literature, the authors consider these three issues as the most significant concerning morbidity and mortality among anabolic steroid users. A study by Parssinen et al. (2000) has shown an increased incidence of premature mortality among power lifters. Anabolic steroids and other concomitantly used drugs are the probable cause of this increased mortality, as power training itself does not increase health risks and all types of physical activity promote health.

 

 

J Sports Med Phys Fitness. 2000 Sep;40(3):271-4.

Reversible hypogonadism and azoospermia as a result of anabolic-androgenic steroid use in a bodybuilder with personality disorder. A case report.

Boyadjiev NP, Georgieva KN, Massaldjieva RI, Gueorguiev SI.

Faculty of Medicine, Department of Physiology, Plovdiv, Bulgaria. nutrim@plovdiv.techno-link.com

 

We report a case of reversible hypogonadism and azoospermia resulting from anabolic-androgenic steroid abuse in a body-builder with primary personality disorder. A keen body builder, a 20-year-old man, developed acute aggressive and destructive behavior after 10-month use of Bionabol (mean total dose of 1,120 mg per month), and Retabolil (mean total dose of 150 mg per month). He was found to meet the Diagnostic and Statistical Manual of Mental Disorders-IV ed. (DSM-IV) criteria for Borderline personality disorder. On admission to the hospital the clinical profile of the patient showed extremely low levels of serum testosterone. Values increased to normal levels 10 months after withdrawal of steroids. The semen was azoospermic at the beginning of the study period, oligospermic five months later, and reached 20 x 10(6) sperm per mL ten months after the steroid discontinuation. Anabolic steroids can greatly affect the male pituitary-gonadal axis. A hypogonadal state, characterized by decreased serum testosterone and impaired spermatogenesis, was induced in the patient. This condition was reversible after the steroid withdrawal, but the process took more than ten months. His personal imbalance could be considered a personality trait rather than a result of the anabolic-androgenic steroid use. There were probably dispositional personality characteristics that contributed to anabolic steroid abuse in our patient. The hypogonadal changes which occurred after his long-term steroid abuse were for the most part reversible.

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Guys....let's face it....some people are out there about to take or may have already taken another dose of steroids and there is nothing we can do to make them change their minds.  My question is, what are the supplements needed to complement with the steroid use so as to compensate/protect (I just don't have a word for it)  for any damage the body may have to endure?

 

 

These "antidotes", unfortunately, do not exist. Doctors who take care of cancer patients, transplant patients, adrenal insufficiency patients, and the like, who are undergoing chronic steroid therapy would very much want the answer to your question, too, so their patients do not have to contend with such side-effects. *med

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